Impact of famotidine on chances of survival in hospitalized COVID-19 patients

Key Messages

The hospitalization records of 1,000 adult COVID-19 patients were retrospectively analyzed, to identify which medications were linked with increased chances of survival.

Famotidine used in the management of COVID-19 patients was linked to significantly higher chance of survival in mild to moderate as well as in severe COVID-19 patients.

IJCP

Publication Date: February 11, 2022
Peer Reviewed: Yes
Publication Type: Original | Clinical Retrospective
DOI: https://ijcp.in/Pages/Post_Detail.aspx?wid=20329

Efficacy of Various Treatment Modalities on Patient-related Outcome in Hospitalized COVID-19 Patients – A Retrospective Study

Farhana Siraj, Nazia Mehfooz, Suhail Mantoo, Afshan Shabir, Tajamul Hussain, Syed Mudasir Qadri, Umar Hafiz, Ajaz Nabi Koul, Mushtaq Dangroo, Muzaffar Bindroo, Fayaz Sofi, Sonaullah Shah, Rafi Jan

Abstract

Background:
The outbreak of coronavirus disease 2019 (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in China, in December 2019, and was declared a pandemic by WHO on March 11, 2020. The treatment is evolving and is mostly supportive in nature.

Material and methods:
This was a single-center retrospective study that included confirmed COVID-19 cases treated at our institute (a tertiary care hospital in Jammu and Kashmir, India), between March 2020 and December 2020. Patients with age more than 18 years were included in the study.

Results:
On evaluating the effect of various drug therapies used in management of COVID-19 patients of all severity, use of remdesivir and famotidine was associated with significantly higher odds of survival. In subgroup of patients with severe disease, use of systemic steroids was associated with significantly higher odds of survival in addition to remdesivir and famotidine. In patients with severe COVID-19 illness, likelihood of survival was significantly higher in those who received combination of systemic steroids plus remdesivir compared to steroids and remdesivir alone.

Conclusion:
Steroids were effective in severe COVID-19 illness and the combination of steroids and remdesivir was more effective in severe illness. There is a need to undertake more large scale prospective randomized trials to determine the most effective drug therapies to treat the sick patients and prevent worsening of mild cases.