What underlies the benefit of famotidine when used to treat COVID-19?

Key Messages

The authors comment on the retrospective study performed by Freedberg and colleagues (2020) that revealed COVID-19 patients taking famotidine have a lower risk for mechanical ventilation and death.

The authors carried out a computerized molecular docking study aimed at identifying famotidine's potential mechanism of action against the SARS-CoV-2 virus.

In contrast to similar studies by others, the authors conclude that famotidine creates only weak bonds with two of the critical SARS-CoV-2 proteases (the papain-like protease PLpro and the 3 chymotrypsin-like protease Mpro), which are unlikely to interfere with their activity.


Publication Date: April 1, 2021
Peer Reviewed: No
Publication Type: Review/Commentary/Letter
DOI: https://www.doi.org/10.1053/j.gastro.2020.07.051

What Underlies the Benefit of Famotidine Formulations Used During COVID-19?

Vijay P. Singh, Bara El-Kurdi, Christopher Rood