Popular Brand Names:
Luvox Luvox CR Faverin
Fluvoxamine is an antidepressant and anti-anxiety drug belonging to a class known as selective serotonin uptake inhibitors (SSRI). It was first approved in 1982, and is used for treating obsessive compulsive disorder (OCD) and major depression.
The original idea of using fluvoxamine to treat COVID-19 originated with Dr. Angela Reiersen, a psychiatrist at Washington University in St. Louis. Years back, she identified fluvoxamine’s unique effects through its ability to activate the Sigma-1 receptor, which reduces inflammation.
Early in the pandemic, in March 2020, Dr. Reiersen shared the idea with Dr. Eric Lenze of the Washington University School of Medicine, and they initiated the first clinical trial in COVID-19 patients, which proved successful.
Since then, a number of trials have been launched and positive results continue to accumulate. Fluvoxamine treatment appears to reduce COVID-19 symptoms, the need for hospitalization, and patient mortality. The doses given in these studies range from 50 mg twice daily to 100 mg three times daily.
Fluvoxamine was the first SSRI approved to treat depression in children. It is used across all age groups.
Fluvoxamine is considered a pleiotropic drug, which means it has multiple unrelated effects on the body. It has off-label uses in a number of medical conditions.
Key Facts for Fluvoxamine
Obsessive Compulsive Disorder (USA, UK)
Major Depressive Episode (UK)
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Fluvoxamine's Anti-COVID Properties
- Antiviral activity against SARS-CoV-2
- Induction of autophagy, the body’s method for clearing out damaged cells
- Inhibits platelet activation, which occurs during blood clotting
- Lowers IL-1 beta, a key mediator of inflammation
- Lowers IL-12 to reduce inflammation
- Lowers IL-6 to reduce inflammation and inhibit acute protein synthesis needed for viral replication
- Lowers IL-8 to reduce inflammation
- Lysosomotropic agent – reduces the ability of the virus to reach its replication site and reduces the release of replicated virus from infected cells
- Raises melatonin levels – melatonin has anti-inflammatory and antiviral properties
- Reduces excessive blood clotting activity
- Activates the Sigma-1 receptor, which reduces inflammation
- Upregulates endocytosis of spike protein – diverts the virus to cellular compartments called early endosomes which reduces the opportunity for viral replication
Fluvoxamine treatment of patients with symptomatic COVID-19 in a community treatment center in Korea
Videos Discussing Fluvoxamine’s Role in COVID
Fluvoxamine for COVID-19: A New Weapon in the Fight?
Dr F. Perry Wilson of the Yale School of Medicine talks about the use of fluvoxamine for treating COVID-19.
Can we use a depression treatment drug to treat COVID? What do we know so far?
Dr. Hong presents the science behind fluvoxamine’s utility for COVID-19.
Fluvoxamine for early treatment of COVID-19: the STOP COVID clinical trials (Eric Lenze, MD)
While using Fluvoxamine to treat anxiety in patients with Wolfram Syndrome, Dr. Reiersen from Washington University, St. Louis learned that Fluvoxamine (Luvox) reduced inflammation and interfered with viral function. Watch this detailed 55 minute presentation by Dr. Eric Lenze as guest of the NIH Grand Rounds program.
More Patients Take Anti-Depressant to Beat COVID Symptoms
For COVID patients who have not been vaccinated, the antidepressant could help save lives. Joel Grover reported on NBC4 News on Monday, March 22, 2021.
Could a psychiatric drug treat COVID?
A psychiatrist at Washington University explains how a clinical trial was launched for the possible use of a 40-year-old antidepressant as a treatment for COVID.
Antidepressant Fluvoxamine Found Efficacious Against COVID-19; FDA Says It’s Safe to Use, Cheap to Produce
Could a commonly prescribed antidepressant be used to treat Covid-19? A new study suggests it’s a possibility. The drug is called fluvoxamine and here’s what you need to know.
Fluvoxamine – Important for Long Haulers – Reduced Clinical Deterioration in COVID
Fluvoxamine – Important for Long Haulers – Reduced Clinical Deterioration in COVID. Study shows reduction of clinical deterioration of patients.
Fluvoxamine and the Early Treatment of COVID: What does the data say?
Dr. Risinger explains the rationale behind the use of fluvoxamine (Luvox) for treating early COVID-19.
Early Outpatient Treatment Of Symptomatic COVID-19 With Fluvoxamine: A New Potential Therapy!
In this video we will discuss a new study that was published in the Journal of the American Medical Association that looked at using Fluvoxamine, a Selective Serotonin Reuptake Inhibitor (SSRI) that also has been shown to inhibit cytokine production, in early outpatient COVID-19.
Clinical Trials of Fluvoxamine in COVID
Effect of Combined Fluvoxamine with Favipiravir versus Favipiravir Monotherapy in Prevention of Clinical Deterioration among mild to moderate COVID-19 patients Monitoring by Telemedicine in Virtual Clinic: Open-label Randomized Controlled Trial
Fluvoxamine 100 mg per day for 10 days
A Multicenter, Prospective, Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Fluvoxamine, Ivermectin, Doxasozin and Interferon Lambda 1A in Mild COVID-19 and High Risk of Complications
100 mg One tablet every 12 hours since randomization through day 09
A Randomized, Double-blind, Placebo-controlled, Adaptive-design Study to Assess the Safety and Efficacy of Daily 200 mg Fluvoxamine as add-on Therapy to Standard of Care in Moderate Severity COVID-19 Patients
2 x 100 mg fluvoxamine daily po. (with careful dose escalation and tapered dose reduction). Overall treatment period is 74 days.
Effect of fluvoxamine medicine on cytokine level of COVID-19 patients, hospitalized in ICU ward
At first, 50 mg will be prescribed per night. after 2 days, 100 mg will be prescribed per night. After 4 days, 100 mg will be prescribed per afternoon and 100 mg will be prescribed per night. After 4 days, 100 mg will be prescribed per morning, 100 mg will be prescribed per afternoon and 100 mg will be prescribed per night.